A Secret Weapon For ceesdekker
A Secret Weapon For ceesdekker
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Nanotechnology features a range of possibilities to lead to biology. Listed here I'll current illustrations where by nanofabrication – a chance to make confined structures with dimensions at will – is used to examine the biophysics of single molecules and cells. I will present some examples from our lab:
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As a human being, I provide the biblical assignment to explore and use every little thing in generation for the good thing about my neighbour. I don't knowledge any conflict concerning faith and science. On the contrary, my faith stimulates me to perform science, to generally be open-minded on the planet.’
Regretably, For a long time after Iijima’s report, the manufacture of clean nanotubes was cumbersome. In 1996, on the other hand, the group of Richard Smalley at Rice University managed to produce solitary-walled carbon nanotubes at superior produce. Soon following, I contacted Smalley, and we chose to join forces to measure the transportation through a solitary carbon nanotube.
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Experimental period diagram of negatively supercoiled DNA measured by magnetic tweezers and fluorescence,
You're a Christian. If you may make this type of artificial cell, would you be one move closer to God, or would the job of God have diminished rather once more?
Movement-pushed rotary motors for instance windmills and h2o wheels drive practical processes in human Culture. While samples of such rotary motors also function prominently in cell biology, their synthetic development within the nanoscale has remained challenging. Right here we exhibit stream-pushed rotary movement of the self-structured DNA nanostructure that may be docked on to a nanopore in a skinny solid-state membrane. An elastic DNA bundle self-assembles into a chiral conformation on phoretic docking on to the good-point out nanopore, and subsequently shows a sustained unidirectional rotary movement of up to twenty rev s−one.
The rotors harness Electrical power from a nanoscale water and ion move that is definitely produced by a static chemical or electrochemical possible gradient during the nanopore, which might be proven through a salt gradient or used voltage, respectively. These artificial nanoengines self-Manage and run autonomously in physiological circumstances, suggesting ways to developing Vitality-transducing motors at nanoscale interfaces.
It had been all through this era that Dekker carried out study on magnetic spin techniques and on sound in superconductors and semiconductors.
An integrated microfluidic platform for quantifying drug permeation across biomimetic vesicle membranes
1999, initial measurement with the wavefunction of single molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive evidence for just a new Luttinger description of interacting electrons in nanotubes
2005, discovery in the system of DNA uncoiling by topoisomerase enzymes; https://www.ceesdekker.net discovery of lengthy-array conformational modifications in Mre11/DNA repair service complexes; and initial pressure measurements on a DNA molecule within a nanopore
Sound-condition nanopores have verified to get a amazingly functional probe for one-molecule Investigation of DNA. I'll describe a number of our latest results – especially DNA knots – along with our attempts to increase the capabilities of solid-point out nanopores even further more, during the way of one-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.